New video is out! I made a code-level walkthrough based on Biohub’s official ESM cookbook tutorial: binder_design.ipynb. The video walks through an end-to-end protein binder design workflow: single…

ESMFold2 can be inverted to design new protein binders including miniproteins and scFvs! Take our protocol for a spin on @modal!

ESMFold2 can be inverted to design new protein binders including miniproteins and scFvTake. Take our protocol for a spin on @modal!

We’ve already said this, there's an AI boom in science now @biohub released Evolutionary Scale Models (ESM) – an open scientific engine for prediction, design, and discovery of protein biology –…

配列言語モデルが、予測・設計・解釈・全体地図化まで担うタンパク質の世界モデルとして機能しうる点が興味深いですね。特に高速複合体予測と大規模探索型設計は、創薬やタンパク質工学の試行回数を大きく広げそう。一方で、安全性や汎化性能、未知機能での実験検証は今後の課題ですね ソースはリプ🔽