polizzilab/NISE

BoltzGen: Toward Universal Binder Design

Generative model for protein binder design for protein and small molecule targets. Combines a pretrained flow-based generative model (built on La-Proteina) with inference-time optimization.

User friendly and accurate binder design pipeline

Easy to use suite for designing a wide range of protein binder modalities.

BindCraft modified to make PyRosetta use and installation optional: no license needed

HalluDesign, a hallucination-driven all-atom framework for the iterative co-optimization and co-design of protein sequences and structures by leveraging the forward pass of a structure prediction model

Official repository for the ProteinDJ protein design pipeline

All-Atom (Including Hydrogen!) Ligand-Conditioned Protein Sequence Design & Sidechain Packing GNN

de novo design of high affinity biological binders