deeptools/pyBigWig

Python wrapper -- and more -- for BEDTools (bioinformatics tools for "genome arithmetic")

Performant Pythonic GenomicRanges

Pysam is a Python package for reading, manipulating, and writing genomics data such as SAM/BAM/CRAM and VCF/BCF files. It's a lightweight wrapper of the HTSlib API, the same one that powers samtools, bcftools, and tabix.

python module to plot beautiful and highly customizable genome browser tracks

Efficient pythonic random access to fasta subsequences

cython + htslib == fast VCF and BCF processing

Python interface to access reference genome features (such as genes, transcripts, and exons) from Ensembl

Jupyter notebook based genomic data visualization toolkit.

C++ library and cmdline tools for parsing and manipulating VCF files with python and zig bindings